Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis
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چکیده
منابع مشابه
Bexarotene induces cellular senescence in MMTV-Neu mouse model of mammary carcinogenesis.
Previous studies have shown that retinoids and rexinoids can prevent breast cancer in animal models and in women with increased risk of developing the disease. The cellular effects of these vitamin A analogues have been primarily associated with induction of differentiation and inhibition of proliferation. In this study, we tested the hypothesis that bexarotene (LGD1069, Targretin), a rexinoid,...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2013
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-12-0260